Why environmental impact assessments often fail

Considering Ecological Processes in Environmental Impact Assessments

Pathophysiology of chronic bacterial osteomyelitis. Why do antibiotics fail so often?

In this review the pathophysiology of chronic bacterial osteomyelitis is summarised, focusing on how bacteria succeed so often in overcoming both host defence mechanisms and antibiotic agents. Bacteria adhere to bone matrix and orthopaedic implants via receptors to fibronectin and to other structural proteins. They subsequently elude host defences and antibiotics by "hiding" intracellularly, by...

Why do phase III clinical trials in oncology fail so often?

Achieving success in the development of a cancer drug continues to be challenging. Given the increasing costs (1) and the small number of drugs that gain regulatory approval (2), it is crucial to understand these failures. In this issue of the Journal, Gan et al. (3) reviewed 235 recently published phase III randomized clinical trials (RCTs). They report that 62% of the trials did not achieve r...

Why Interventions to Influence Adolescent Behavior Often Fail but Could Succeed.

We provide a developmental perspective on two related issues: (a) why traditional preventative school-based interventions work reasonably well for children but less so for middle adolescents and (b) why some alternative approaches to interventions show promise for middle adolescents. We propose the hypothesis that traditional interventions fail when they do not align with adolescents' enhanced ...

Why Reengineering Projects Fail

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